Epimorphin Mediates Mammary Luminal Morphogenesis through Control of C/EBPβ

  title={Epimorphin Mediates Mammary Luminal Morphogenesis through Control of C/EBPβ},
  author={Yohei Hirai and D. Radisky and Rosanne M Boudreau and Marina Simian and M. D. Cladd E. Stevens and Yumiko Oka and Kyoko Takebe and Shinichiro Niwa and Mina J. Bissell},
  journal={The Journal of Cell Biology},
  pages={785 - 794}
We have shown previously that epimorphin (EPM), a protein expressed on the surface of myoepithelial and fibroblast cells of the mammary gland, acts as a multifunctional morphogen of mammary epithelial cells. Here, we present the molecular mechanism by which EPM mediates luminal morphogenesis. Treatment of cells with EPM to induce lumen formation greatly increases the overall expression of transcription factor CCAAT/enhancer binding protein (C/EBP)beta and alters the relative expression of its… CONTINUE READING


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