Epimerization and racemization of some chiral drugs in the presence of human serum albumin.

  title={Epimerization and racemization of some chiral drugs in the presence of human serum albumin.},
  author={Yukio Aso and S. Yoshioka and Y Takeda},
  journal={Chemical \& pharmaceutical bulletin},
  volume={38 1},
Epimerization and racemization of carbenicillin, ethiazide, etoposide and oxazepam acetate were examined kinetically in the presence of human serum albumin (HSA). The concentration of both optical isomers of each drug was determined by stereospecific high-performance liquid chromatography. The apparent rate constants of epimerization or racemization and hydrolysis were estimated from the concentration-time data. HSA retarded the racemization of ethiazide and the epimerization of etoposide. The… 

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