Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo.

@article{Ruszov2013EpilobiumAE,
  title={Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo.},
  author={Ema Ruszov{\'a} and Jos{\'e} Cheel and Stanislav P{\'a}vek and Martina Moravcov{\'a} and Martina Hermannov{\'a} and Ilona Matějkov{\'a} and Jiřina Spilkov{\'a} and Vladim{\'i}r Velebn{\'y} and Luk{\'a}{\vs} Kubala},
  journal={General physiology and biophysics},
  year={2013},
  volume={32 3},
  pages={
          347-59
        }
}
Stress-induced fibroblast senescence is thought to contribute to skin aging. Ultraviolet light (UV) radiation is the most potent environmental risk factor in these processes. An Epilobium angustifolium (EA) extract was evaluated for its capacity to reverse the senescent response of normal human dermal fibroblasts (NHDF) in vitro and to exhibit skin photo-protection in vivo. The HPLC-UV-MS analysis of the EA preparation identified three major polyphenol groups: tannins (oenothein B), phenolic… 

Figures and Tables from this paper

Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway
TLDR
Mechanistically, the hyperoside-enriched fraction obtained from H. cordata inhibited UVB-irradiated skin aging through regulation of the MAPK signaling pathway by attenuating the activation of JNK/ERK/c-Jun in human dermal fibroblasts.
Epilobium angustifolium L. as a Potential Herbal Component of Topical Products for Skin Care and Treatment—A Review
TLDR
The aim of the article is to review the existing literature on the dermocosmetic use of E. angustifolium to ensure that the available scientific information on the biological potential of natural compounds can be the basis for the wider use of EA in skin care and treatment.
Antioxidant Properties of Plant-Derived Phenolic Compounds and Their Effect on Skin Fibroblast Cells
TLDR
Phenolics are a good candidate for eliminating the causes of skin damage including wounds and aging and acting as skin care agents.
In Vitro Human Skin Penetration, Antioxidant and Antimicrobial Activity of Ethanol-Water Extract of Fireweed (Epilobium angustifolium L.)
TLDR
In vitro penetration studies of fireweed ethanol-water extracts showed the penetration of some phenolic acids and their accumulation in the skin, confirming the importance of skin penetration studies to guarantee the efficacy of formulations containing E. angustifolium extracts.
Modulation of keratin 1, 10 and involucrin expression as part of the complex response of the human keratinocyte cell line HaCaT to ultraviolet radiation
TLDR
The data suggest that the expression of keratin 1, 10 and involucrin is modulated in HaCaT keratinocytes as a part of the complex stress response to UV radiation.
Epilobium angustifolium L. Extracts as Valuable Ingredients in Cosmetic and Dermatological Products
TLDR
The obtained results indicate that E. angustifolium may be an interesting plant material to be applied as a component of cosmetic and dermatological preparations with antiaging and anti-inflammatory properties.
Epilobium Hirsutum L and Malva Neglecta L . Propylene Glycol Extracts for Cosmetic Use ; Chemical Composition , Microbiological Stability and Diffusion Aspects
Original Research Article Plant derived products provide numerous beneficial effects on the human skin; for example, the moisturizing effect, the capacity of stimulation of collagen and elastin
An overview about oxidation in clinical practice of skin aging*
TLDR
The main evidence of the benefits brought by the topical application of antioxidants in the skin is summarized, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests.
Assessment of the Anti-Inflammatory, Antibacterial and Anti-Aging Properties and Possible Use on the Skin of Hydrogels Containing Epilobium angustifolium L. Extracts
TLDR
In vitro penetration studies showed that the active ingredients contained in E. angustifolium penetrate through human skin and accumulate in it, and can be considered as an interesting alternative for dermatologic and cosmetic preparations.
...
...

References

SHOWING 1-10 OF 52 REFERENCES
Photoprotective effects of glucomannan isolated from Candida utilis.
Overexpression of Phospholipid-hydroperoxide Glutathione Peroxidase in Human Dermal Fibroblasts Abrogates UVA Irradiation-induced Expression of Interstitial Collagenase/Matrix Metalloproteinase-1 by Suppression of Phosphatidylcholine Hydroperoxide-mediated NFκB Activation and Interleukin-6 Release*
TLDR
UVA irradiation-induced PCOOHs and subsequent lipid peroxides initiate the NFκB-mediated induction of IL-6, which mediates the induction of MMP-1, and this finding is particularly relevant in light of the already available small molecule mimetics of PHGPx.
A red wine polyphenolic extract reduces the activation phenotype of cultured human liver myofibroblasts.
TLDR
Red wine polyphenolic extract decreases the activation state of liver myofibroblasts and could offer new therapeutic strategies against liver fibrosis, according to the identification of the active compounds in RWPE.
Subtoxic oxidative stress induces senescence in retinal pigment epithelial cells via TGF-beta release.
TLDR
Reduction of oxidative stress and minimizing TGF-beta may help to prevent senescence-associated changes in the RPE as seen in early age-related macular degeneration.
Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-β1 signaling pathway
TLDR
This model represents an alternative in vitro model in photoaging research for screening potential anti-photoaging compounds and suggests a role for TGF-β1 in UVB-induced premature senescence.
Subcytotoxic H2O2 Stress Triggers a Release of Transforming Growth Factor-β1, Which Induces Biomarkers of Cellular Senescence of Human Diploid Fibroblasts*
TLDR
Results obtained on fibroblasts retrovirally transfected with the human papillomavirus E7 cDNA suggest that retinoblastoma protein (Rb) regulates the expression of TGF-β1 in stressful conditions, leading to SIPS and overexpression of these four genes.
Characterization of the Effect of Epilobium Extracts on Human Cell Proliferation
TLDR
Results indicate that Epilobium extracts inhibit proliferation of prostate cells in a nonspecific manner, and oenothein B may play a role in this effect, but other active compounds are also present.
Extract of Lillium candidum L. Can Modulate the Genotoxicity of the Antibiotic Zeocin
TLDR
It is shown for the first time that LE can modulate the genotoxic effects of zeo, and revealed that LE-induced AR to zeocin involves up-regulation of DSB rejoining in C. reinhardtii and P. vulgare L. cells.
Oenothein B's contribution to the anti-inflammatory and antioxidant activity of Epilobium sp.
...
...