Epiligrin, the major human keratinocyte integrin ligand, is a target in both an acquired autoimmune and an inherited subepidermal blistering skin disease.

@article{DomlogeHultsch1992EpiligrinTM,
  title={Epiligrin, the major human keratinocyte integrin ligand, is a target in both an acquired autoimmune and an inherited subepidermal blistering skin disease.},
  author={N Domloge-Hultsch and W R Gammon and Robert A. Briggaman and Susana G. Gil and William Gene Carter and Kim B. Yancey},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 4},
  pages={1628-33}
}
Epiligrin, the major component of human keratinocyte extracellular matrix, serves as the preferred integrin ligand for alpha 3 beta 1 in plasma membranes and focal adhesions, and colocalizes with alpha 6 beta 4 in hemidesmosomes. In human skin, epiligrin is found in the lamina lucida subregion of epidermal basement membrane, where it is thought to be associated with anchoring filaments. We have identified three patients with an acquired mucosal predominant subepidermal blistering disease who… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…