Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers.

@article{Dub2010EpileptogenesisPB,
  title={Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers.},
  author={C{\'e}line M. Dub{\'e} and Teresa Ravizza and Mark J. Hamamura and Qinqin Zha and Andrew J Keebaugh and Kimberly Fok and Adrienne L. Andres and Orhan Nalcioglu and Andre Obenaus and Annamaria Vezzani and Tallie Z. Baram},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 22},
  pages={7484-94}
}
Whether long febrile seizures (FSs) can cause epilepsy in the absence of genetic or acquired predisposing factors is unclear. Having established causality between long FSs and limbic epilepsy in an animal model, we studied here if the duration of the inciting FSs influenced the probability of developing subsequent epilepsy and the severity of the spontaneous seizures. We evaluated if interictal epileptifom activity and/or elevation of hippocampal T2 signal on magnetic resonance image (MRI… CONTINUE READING