Epileptic spasms — 175 years on: Trying to teach an old dog new tricks

@article{Wilmshurst2017EpilepticS,
  title={Epileptic spasms — 175 years on: Trying to teach an old dog new tricks},
  author={Jo M. Wilmshurst and Roland Chidi Ibekwe and Finbar O'callaghan},
  journal={Seizure},
  year={2017},
  volume={44},
  pages={81-86}
}

Treatment of infantile spasms: why do we know so little?

No new therapeutic options for IS have emerged, probably due to the lack of reliable animal models and to the extreme variability in etiologies, Consequently, the outlook for patients and families is poor and early recognition and intervention remain research priorities.

Early surgical intervention for structural infantile spasms in two patients under 6 months old: a case report

Early resection of lesions in structural IS patients has benefits of effectively controlling convulsions and improving developmental retardation, and infants at several months of age can well tolerate craniotomy, and their cognitive development is more likely to return to normal after early surgery.

West Syndrome: A Review and Guide for Paediatricians

Considering that an early diagnosis and a shorter lag time to treatment are essential for successful outcomes in these patients, further studies on efficacy of the different therapeutic approaches with evaluation of final outcome after cessation of therapy are needed.

Effectiveness of ACTH in Patients with Infantile Spasms

Randomized controlled clinical trials with long-term follow-up are needed to compare the effectiveness of ACTH in polytherapy and monotherapy and to investigate Dyskinesias as a potential side effect observed in the study group.

West syndrome: a comprehensive review

This condition is currently regarded as a spectrum of disorders: the so-called infantile spasm syndrome (ISs), in association with other causal factors, including structural, infectious, metabolic, syndromic, and immunologic events, all acting on a genetic predisposing background.

Early Intervention With Adrenocorticotropin for Acute Encephalopathy-Associated Epileptic Spasms: Report of Two Cases

The potential efficacy of ACTH for a group of children with epileptic spasms after AESD is illustrated, and it has relieved these patients from epileptic seizures for more than 1 year.

Factors predictive of prognosis of infantile spasms. A retrospective study in a low-income country.

Neurodevelopmental and epilepsy outcomes of patients with infantile spasms treated in a tertiary care center

Neurodevelopmental outcomes of IS are strongly associated with the underlying etiology and early initiation of treatments had a favorable cognitive and motor outcome.

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