Epileptic spasms — 175 years on: Trying to teach an old dog new tricks

  title={Epileptic spasms — 175 years on: Trying to teach an old dog new tricks},
  author={Jo M. Wilmshurst and Roland Chidi Ibekwe and Finbar O'callaghan},

Treatment of infantile spasms: why do we know so little?

No new therapeutic options for IS have emerged, probably due to the lack of reliable animal models and to the extreme variability in etiologies, Consequently, the outlook for patients and families is poor and early recognition and intervention remain research priorities.

Early surgical intervention for structural infantile spasms in two patients under 6 months old: a case report

Early resection of lesions in structural IS patients has benefits of effectively controlling convulsions and improving developmental retardation, and infants at several months of age can well tolerate craniotomy, and their cognitive development is more likely to return to normal after early surgery.

West Syndrome: A Review and Guide for Paediatricians

Considering that an early diagnosis and a shorter lag time to treatment are essential for successful outcomes in these patients, further studies on efficacy of the different therapeutic approaches with evaluation of final outcome after cessation of therapy are needed.

Effectiveness of ACTH in Patients with Infantile Spasms

Randomized controlled clinical trials with long-term follow-up are needed to compare the effectiveness of ACTH in polytherapy and monotherapy and to investigate Dyskinesias as a potential side effect observed in the study group.

West syndrome: a comprehensive review

This condition is currently regarded as a spectrum of disorders: the so-called infantile spasm syndrome (ISs), in association with other causal factors, including structural, infectious, metabolic, syndromic, and immunologic events, all acting on a genetic predisposing background.

Early Intervention With Adrenocorticotropin for Acute Encephalopathy-Associated Epileptic Spasms: Report of Two Cases

The potential efficacy of ACTH for a group of children with epileptic spasms after AESD is illustrated, and it has relieved these patients from epileptic seizures for more than 1 year.

Factors predictive of prognosis of infantile spasms. A retrospective study in a low-income country.

Neurodevelopmental and epilepsy outcomes of patients with infantile spasms treated in a tertiary care center

Neurodevelopmental outcomes of IS are strongly associated with the underlying etiology and early initiation of treatments had a favorable cognitive and motor outcome.



Treatment of Infantile Spasms: Medical or Surgical?

This finding suggests that focal cortical abnormalities can cause infantile spasms and that removing the abnormality can stop the seizures.

Diagnosis and prognosis of hypsarhythmia and infantile spasms.

In the course of electroencephalographic studies on patients with epilepsy an abnormal pattern has been found that is peculiar to infants and young children. It occurs in patients with brief

The Epidemiology and Natural History of Infantile Spasms

This review attempts to summarize what is known about the distribution, etiology, and natural history of infantile spasms in populations; discusses the limitations of current data; and includes suggestions for further population-based research.

Benign myoclonus of early infancy or benign non-epileptic infantile spasms.

The spasms are clinically similar to those often observed in West syndrome; namely they are characterized by a short (2-4 sec.) tonic contraction, there are no significant changes of the EEG concomitant to the spasm.

Observations on the Antagonistic Effects of Posterior Pituitary and Cortico-Adrenal Hormones in, the Epileptic Subject1

Recent developments in the use of the electroencephalograph for recording the electrical potentials of the brain (i.e., the so-called ‘brain waves’) have demonstrated beyond any question that the symptom which the authors recognise a...

Etiology and Long-Term Outcomes of Late-Onset Infantile Spasms.

Cognitive outcome of LOS was more favorable than in the previous reports and was associated with seizure freedom and FCD1 is a frequent etiology for LOS and the cognitive outcome of patients with F CD1 seemed to be favorable.

Infantile spasms in Down syndrome—effects of delayed anticonvulsive treatment