Epileptic Seizures after Treatment with Thiocolchicoside

  title={Epileptic Seizures after Treatment with Thiocolchicoside},
  author={P L De Riu and Giulio Rosati and Stefano Sotgiu and GianPietro Sechi},
Summary:  Purpose: To report the occurrence of epileptic seizures in humans, closely related to the use of the centrally acting muscle relaxant thiocolchicoside. 
Epileptic seizure after treatment with thiocolchicoside
It is indicated that thiocolchicoside can precipitate seizures in predisposed patients, and that its use should be avoided in patients with brain diseases (and therefore lower seizure thresholds) or blood–brain barrier disruption.
Temporary Seizure in an Infant Who Had Been Exposed to G-Amino Butyric Acid Receptor Antagonist Thiocolchicoside.
A previously healthy 3-month-old female infant who was admitted to the emergency department with a generalized seizure after exposure to TCC via breastfeeding is presented, believed to be the first case of a child who had an epileptic seizure after TCC intake via breastfeeding in the literature.
Thiocolchicoside-induced liver injury
, but other systemic side effects, such ascardiotoxicity, nephrotoxicity or hepatotoxicity, have notbeen reported. Here, we report the case of a patient whosehepatic and cholestatic enzyme levels
Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat
It is documents that thiocolchicoside has a powerful convulsant activity in the rat, perhaps due to an antagonistic interaction of the compound with a cortical subtype of the GABA(A) receptor.
Benzodiazepine withdrawal syndrome induced by thiocolchicoside
It is hypothesized that thiocolchicoside induced a benzodiazepine withdrawal syndrome due to GABAAR antagonism, and the rapid reversion of symptoms following benzdiazepine intake supports this hypothesis.
The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system
The data suggest that TCC is a potent competitive antagonist of GABAAR function, consistent with clinical observations of the epileptogenic effect of this compound, and a proposed agonistic action at two types of inhibitory receptors.
Alive Animal Model for Epilepsy by Intradorsal Striatum Injection of Colchicine
The colchicine, using injection successively into the dorsal striatal region of rat, can create recurring epileptic convulsions in the animal, and tissue damage was invisible in the target brain area.
Injection of colchicine into the dorsal striatum of rat's brain induces epilepsy
The plant-derived alkaloid, the colchicine, aside depolymerizing of tubulin, may have an inductive effect on epilepsy in the complementary motor striatal region of the rat's brain.
Hypothyroıdısm and Drug-Related Rhabdomyolısıs and Acute Kıdney Injury
Case Report Rhabdomyolysis (RM) due to hypothyroidism is known, but acute kidney injury (AKI) due to hypothyroidism related RM is rare and potentially life-threatening. In our first case, a
Selective serotonin reuptake inhibitor poisoning: An evidence-based consensus guideline for out-of-hospital management
A review of US poison center data for 2004 showed over 48,000 exposures to selective serotonin reuptake inhibitors (SSRIs) could potentially optimize patient outcome, avoid unnecessary emergency department visits, reduce health care costs, and reduce life disruption for patients and caregivers.


The colchicine experimental epileptic focus: an intracellular study
A new experimental epileptic focus is described in which colchicine is topically applied to neocortex. Stable epileptiform discharges developed, with bursts of action potentials, coincident with the
Epilepsy, a Product of Trauma in our Time
Using data obtained by the National Center for Health Statistics through household interviews, an estimate of 8,100,000 cases of head injury was determined for the civilian population of the United States in 1974, and the following gradation of posttraumatic epilepsy is predicted for the 1,900,000 with the greater implication of brain damage.
The role of prefrontal cortex in grand mal convulsion.
In five patients with intractable generalized seizures and nonfocal electroencephalograms, direct brain recordings were made at rest, during spontaneously occurring seizure, and during pentylenetetrazol induced grand mal convulsion, indicating an important role for prefrontal cortex in the genesis of both idiopathic and acquired grand mal Convulsion.
Interaction of thiocolchicoside with [3H]strychnine binding sites in rat spinal cord and brainstem.
The results suggest that thiocolchicoside behaves as an allosteric compound acting on the strychnine-sensitive glycine receptor in rat brainstem and spinal cord, and that this may provide a possible mechanism for the myorelaxant activity of this colchicOSide derivative.
Cerebral Seizures of Probable Orbitofrontal Origin
It is felt that a posterior orbitofrontal and temporo‐limbic relationship exists, within which autonomous epileptogenic zones may develop, with the ability to discharge directly and independently to subcortical centers, while eliciting similar clinical patterns.
Adverse drug reactions. A critical review.
To evaluate the impact as well as the causes of ADRs, representative populations must be studied, and operationally defined criteria must be used to establish the presence of an ADR in a prospective study that incorporates appropriate control populations.
Epileptogenic activity of thiocolchicoside [Abstract
  • Epilepsia
  • 1993
Effect of colchicine on synaptic transmission and long-term potentiation of the dentate gyrus
  • Neurosci Abstr1982;8:215.4
  • 1982