Epileptic Seizures May Begin Hours in Advance of Clinical Onset A Report of Five Patients

  title={Epileptic Seizures May Begin Hours in Advance of Clinical Onset A Report of Five Patients},
  author={Brian Litt and Rosana Esteller and Javier Echauz and Maryann D'Alessandro and Rachel Shor and Thomas Henry and Page B. Pennell and C. Epstein and R. Bakay and Marc A. Dichter and George Vachtsevanos},
Mechanisms underlying seizure generation are traditionally thought to act over seconds to minutes before clinical seizure onset. We analyzed continuous 3- to 14-day intracranial EEG recordings from five patients with mesial temporal lobe epilepsy obtained during evaluation for epilepsy surgery. We found localized quantitative EEG changes identifying prolonged bursts of complex epileptiform discharges that became more prevalent 7 hr before seizures and highly localized subclinical seizure-like… CONTINUE READING
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