Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

@article{Kash1997EpilepsyIM,
  title={Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.},
  author={Shera F Kash and Richard S Johnson and Laurence H. Tecott and Jeffrey L Noebels and R Dayne Mayfield and Douglas Hanahan and Steinunn Baekkeskov},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 25},
  pages={14060-5}
}
gamma-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian brain, is synthesized by two glutamate decarboxylase isoforms, GAD65 and GAD67. The separate role of the two isoforms is unknown, but differences in saturation with cofactor and subcellular localization suggest that GAD65 may provide reserve pools of GABA for regulation of inhibitory neurotransmission. We have disrupted the gene encoding GAD65 and backcrossed the mutation into the C57BL/6 strain of mice. In… CONTINUE READING
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