Epilepsy in later life

@article{Brodie2009EpilepsyIL,
  title={Epilepsy in later life},
  author={Martin J Brodie and Andrew T Elder and Patrick Kwan},
  journal={The Lancet Neurology},
  year={2009},
  volume={8},
  pages={1019-1030}
}
Epilepsy is most likely to develop in later life. The burden of this disorder on health-care resources will rise further as the world's population continues to age. Making a secure diagnosis can be challenging because the clinical manifestations of seizures and the differential diagnoses and causes of epilepsy can be different in older individuals compared with younger individuals. Obtaining a reliable account of the events for accurate assessment is particularly important in guiding the… Expand
[Epilepsy in the elderly].
TLDR
A discretionary selection of original articles and reviews found in PubMed using the search term combination 'epilepsy' and 'elderly' and the authors' personal experience are used to provide guidance on the management of epilepsy in this patient group. Expand
Epilepsy in the Elderly: Treatment and Consideration of Comorbid Diseases
  • S. Lee
  • Medicine
  • Journal of epilepsy research
  • 2019
TLDR
The optimal quality of life of dementia patients cannot be achieved without a proper diagnosis of coexisting epilepsy, and antiepileptic drugs with fewer adverse effects, including cognitive effects, and AEDs without significant pharmacokinetic drug interactions are needed. Expand
Challenges in the pharmacological management of epilepsy and its causes in the elderly.
TLDR
Evidences from double-blind and open-label studies indicate lamotrigine, levetiracetam and controlled-release carbamazepine as first line treatment in late-onset epilepsy. Expand
Treatment of Epilepsy in the Elderly
TLDR
Familiarity with anti-epileptic medication dosing and titration schedules, possible adverse effects, and potential pharmacokinetic and drug interactions can be helpful when considering treatment options and may increase the likelihood of success. Expand
Selection of Antiepileptic Drugs in Older People
TLDR
There is no ideal drug for this patient population, although most newer anticonvulsants have the advantage of a favorable pharmacokinetic profile, minimal or no drug–drug interactions, and fewer adverse events, as well as being well tolerated. Expand
Epilepsy in older people
TLDR
The need for clinical trials to be more inclusive of older people with epilepsy to help inform therapeutic decision making is emphasised and whether measures to improve vascular risk factors might be an important strategy to reduce the probability of developing epilepsy is discussed. Expand
Pharmacotherapy for epilepsy in the elderly
TLDR
There is emerging evidence that newer anti‐epileptics such as levetiracetam and gabapentin are better tolerated and some older agents such as phenytoin should be avoided due to the risks of toxicity and drug interactions. Expand
Addressing the burden of epilepsy: Many unmet needs.
  • E. Beghi
  • Medicine
  • Pharmacological research
  • 2016
TLDR
As being a fairly common clinical condition affecting all ages and requiring long-term treatment, epilepsy carries high health care costs for the society and direct costs peak in the first year after diagnosis and then vary according to the severity of the disease, the response to treatment, and the presence of comorbidity. Expand
Epilepsy in the Elderly
TLDR
Seizure freedom after epilepsy surgery is achieved in more than half of the patients and significant seizure reduction in majority of patients and new generation of antiepileptic medications such as LEV and LTG can be suggested as initial treatment based on lower rate of potential side effects and lesser extend of pharmacokinetic interactions. Expand
New‐onset epilepsy in the elderly
TLDR
It is found that there is limited evidence to guide treatment in people with Alzheimer's disease and epilepsy, and the specific features of new‐onset epilepsy in this target population significantly influences the choice of treatment. Expand
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TLDR
Anti-epileptic drugs (AED) should be started only after the diagnosis has been clearly established, when the risk of recurrence is high, and with monotherapy whenever possible, although few data are available, the more recent AED offer significant advantages over the older medications. Expand
Epilepsy in elderly people
TLDR
A coordinated programme among health-care workers is advised to maintain the independence and improve the quality of life of this vulnerable patient population. Expand
Epilepsy in elderly people
TLDR
A coordinated programme among health-care workers is advised to maintain the independence and improve the quality of life of this vulnerable patient population. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Results indicated that HRQOL and psychosocial functioning in the epilepsy group was significantly impaired relative to normal controls, and a greater perception of stigma and more frequent seizures was also strongly related to poor quality of life and reduced psychossocial function. Expand
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TLDR
Monotherapy should remain the treatment of choice for newly diagnosed epilepsy and a combination of two AEDs can be considered after failure, resulting from lack of efficacy, of one or two different monotherapy regimens. Expand
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