Epilepsy in individuals with neurofibromatosis type 1

  title={Epilepsy in individuals with neurofibromatosis type 1},
  author={Adam P. Ostendorf and David H. Gutmann and Judith L. Z. Weisenberg},
To describe the clinical characteristics and outcomes of individuals with neurofibromatosis type 1 (NF1) and seizures in the largest cohort reported to date. 

Neurological comorbidity in children with neurofibromatosis type 1

The aim of this study was to determine the frequency of central nervous system comorbidities in children with neurofibromatosis type 1 (NF1).

Cutaneous and Systemic Findings in Mosaic Neurofibromatosis Type 1

The objective was to characterize the cutaneous features and associated systemic findings in a cohort of children with MNF1.

Phakomatoses-Neurocutaneous Syndromes

This chapter will discuss the systemic and ocular findings for each of the phakomatoses, a heterogeneous group of neurocutaneous syndromes with hamartomas in multiple organ systems including skin and the central nervous system.

Seizures in Adult with Neurofibromatosis Type 1

This chapter is aimed to explain the types of seizures, EEG features and the properties of drug therapy in NF1.

A Neurocutaneous Syndrome Proceeding with Pigmentation Disorder: Neurofibromatosis Type 1

Neurofibromatosis type 1 is a relatively common inherited disease. The condition may involve frequently difficult to manage benign and malignant tumors in affected patients and can also affect

Neurofibromatosis type-1 with seizures and cerebrovascular malformation: a case study

Patients with NF1 may present with a variety of central nervous system complaints, such as seizures, learning disability and attention-deficit disorder, and cerebrovascular diseases,such as Moyamoya syndrome, have been reported but found to be rare.

Epilepsy in neurofibromatosis type 1

Glioma-Induced Seizure in a Neurofibromatosis Type 1 Patient: A Case Report

A 20-year-old male with a diagnosis of NF-1 presented to the emergency room of a local hospital for the evaluation of an unwitnessed seizure characterized by loss of consciousness and bladder control and displayed sudden aggression and combativeness, which suggested a possible etiology for high seizure frequency in patients withNF-1 compared to the general population.



von Recklinghausen neurofibromatosis.

A large number of the patients diagnosed with neurofibromatosis are women, and the prognosis is poor for the vast majority of the women diagnosed with the disease.

Epidemiology of epilepsy in children.

The convulsive disorders are among the more frequently occurring neurologic disorders of childhood, affecting more than 4% of all children, and shows wide geographic variation and is usually benign.

Neurofibromatosis: Phenotype, Natural History and Pathogenesis

NF1: historical background and introduction clinical and epidemiologic features evaluation and management genetics molecular biology and pathogenesis neurofibromas and malignanat peripheral nerve


Epilepsy in Neurofibromatosis 1

Observations and re-evaluation of the literature indicate that patients with neurofibromatosis 1 have an increased risk of epilepsy related to intracranial masses and cytoarchitectural abnormalities, and seizures can represent the first symptom of a tumor or cortical malformation.

Patterns of Seizures Observed in Association with Neurofibromatosis 1

Clinical features of seizures occurring in a neurofibromatosis clinic population were examined in a retrospective study, finding that seizures appear to be relatively uncommon in individuals with NF1, and when they occur have a natural history similar to that of seizures in the general population.

Type 1 neurofibromatosis: a descriptive analysis of the disorder in 1,728 patients.

The age-specific prevalence of most manifestations of NF1 increases with age, and the frequencies of many of the serious manifestations ofNF1 are similar to those of two smaller population-based studies.

Clinical Presentation of Patients With Neurofibromatosis Type 1 in Infancy and Childhood: Genetic Traits and Gender Effects

It is suggested that genetic traits, especially through the passage of several generations of women, may affect the clinical presentation in patients with neurofibromatosis type 1.

Parent-of-origin in individuals with familial neurofibromatosis type 1 and optic pathway gliomas

Results indicate no parent-of-origin effect overall or by patient sex for OPGs in NF1, unlike findings from other studies of sporadic cancers and cancer predisposition syndromes.

Seizures in neurofibromatosis 1.