Epilepsy in Pregnancy

  title={Epilepsy in Pregnancy},
  author={Manijeh Kamyar and Michael W. Varner},
  journal={Clinical Obstetrics and Gynecology},
Over 25,000 epileptic women deliver viable pregnancies each year in the United States. Although medical management is the first line of treatment, many physiological changes associated with pregnancy can make optimal treatment challenging. Medication dosage is adjusted based on side effects and seizure frequency, with the goal being no seizures with the lowest medication dosage(s) and side-effect profile possible. Whenever possible, monotherapy is preferred. Many antiepileptic drugs have… 

Neurologic complications in critically ill pregnant patients.

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  • Medicine, Psychology
    Handbook of clinical neurology
  • 2017

Evaluation of Seizures in Pregnant Women in Kerman, Iran

More than 6 in 1,000 pregnant women suffer from epilepsy, with eclampsia was the most prevalent cause and epilepsy was observed more in nulliparous women.

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A large-scale retrospective case–control analysis of pregnancies affected by depression, epilepsy or drug abuse with and without medication was conducted in two German perinatal centres between 2013 and 2017, demonstrating a negative association between maternal neurological or psychiatric disease and pregnancy outcome in the examined parameters.

[Anesthesia for cesarean section in patients with preexisting neurologic diseases--10 years of practice].

No guidelines for anesthesiologist concerning the best anesthetic technique for patients with neurological diseases have been designed so far and the choice of the safest method is made individually and depends on a variety of factors.

Critical care in pregnancy--is it different?

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General principles of ICU management will be discussed as applied to obstetric ICU patients, which include drug safety, monitoring the fetus, management of the airway, sedation, muscle relaxation, ventilation, cardiovascular support, thromboprophylaxis, and radiology and ethical issues.

Bicuspid aortic valve and severe aortic stenosis in a newborn exposed to carbamazapine during pregnancy.

An infant who had a history of in-utero carbamazepine exposure and who was born with a cardiac malformation is reported, which indicates bicuspid aorta and aortic stenosis may be among the cardiac malformations that result from the teratogenic effect of carbamazepsine.

Cardiac Arrest in Pregnancy: A Scientific Statement From the American Heart Association

This document will provide readers with up-to-date and comprehensive information, guidelines, and recommendations for all aspects of maternal resuscitation.

What the nonneurologist can do to treat headache.

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  • Medicine, Psychology
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Bei einer Risikoschwangerschaft besteht ein erhohtes Risiko fur das Leben and die Gesundheit von Mutter oder Kind, um fur Mutter and Kind die bestmogliche Betreuung zu gewahrleisten.



The management of epilepsy in pregnancy

The most recent data from the AED registries regarding malformations is presented in this review, as is the limited data on the newer AEDs and studies linking neurocognitive outcomes to AED exposure.

Antiepileptic drugs and pregnancy outcomes

The purpose of this document is to review the most commonly used compounds in the treatment of WWE, and to provide information on the latest experimental and human epidemiological studies of the effects of AEDs in the exposed embryos.

Pregnancy in women who have epilepsy.

Epileptic disorders in pregnancy: an overview

The use of valproate and polytherapy with any AED combinations should be avoided, if clinically appropriate, during pregnancy, with frequent monitoring during pregnancy as appropriate for the patient and the AED.

Seizure control in antiepileptic drug‐treated pregnancy

It was found that pregnancy had little influence on antiepileptic drug‐treated epileptic seizure disorders, and once there had been 1 year's freedom from seizures there seemed relatively little further advantage in deferring pregnancy to avoid seizures returning while pregnant.

Practice Parameter update: Management issues for women with epilepsy—Focus on pregnancy (an evidence-based review): Obstetrical complications and change in seizure frequency

Women with epilepsy (WWE) should be counseled that seizure freedom for at least 9 months prior to pregnancy is probably associated with a high rate (84%–92%) of remaining seizure-free during pregnancy (Level B), however, WWE who smoke should be Counseled that they possibly have a substantially increased risk of premature contractions and premature labor and delivery during pregnancy.

Practice Parameter update: Management issues for women with epilepsy—Focus on pregnancy (an evidence-based review): Teratogenesis and perinatal outcomes

Reassessment of evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy finds it highly probable that intrauterine first-trimester valproate (VPA) exposure has higher risk of major congenital malformations (MCMs) compared to carbamazepine and possible compared to phenytoin or lamotrigine.

Predictors of seizures during pregnancy in women with epilepsy

Pre prepregnancy seizure was the most important predictor of seizures during pregnancy on multiple logistic regression, and women with partial seizures‐had higher risk of relapse than those with generalized seizures.

Pregnancy and perinatal outcome in epileptic women: A population-based study

  • O. KatzA. LevyA. WiznitzerE. Sheiner
  • Medicine, Psychology
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2006
The course of pregnancy of patients with epilepsy is favorable, except for higher rates of cesarean deliveries, GDM, and congenital malformations, which are found among epileptic women.