Epilepsy-associated alterations in hippocampal excitability.

@article{Navidhamidi2017EpilepsyassociatedAI,
  title={Epilepsy-associated alterations in hippocampal excitability.},
  author={Mojdeh Navidhamidi and Maedeh Ghasemi and Nasrin Mehranfard},
  journal={Reviews in the neurosciences},
  year={2017},
  volume={28 3},
  pages={
          307-334
        }
}
The hippocampus exhibits a wide range of epilepsy-related abnormalities and is situated in the mesial temporal lobe, where limbic seizures begin. These abnormalities could affect membrane excitability and lead to overstimulation of neurons. Multiple overlapping processes refer to neural homeostatic responses develop in neurons that work together to restore neuronal firing rates to control levels. Nevertheless, homeostatic mechanisms are unable to restore normal neuronal excitability, and the… CONTINUE READING

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