Epilepsy and cognitive impairments in Alzheimer disease.

  title={Epilepsy and cognitive impairments in Alzheimer disease.},
  author={Jorge J. Palop and Lennart Mucke},
  journal={Archives of neurology},
  volume={66 4},
Alzheimer disease (AD) is associated with cognitive decline and increased incidence of seizures. Seizure activity in AD has been widely interpreted as a secondary process resulting from advanced stages of neurodegeneration, perhaps in combination with other age-related factors. However, recent findings in animal models of AD have challenged this notion, raising the possibility that aberrant excitatory neuronal activity represents a primary upstream mechanism that may contribute to cognitive… CONTINUE READING
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