Epilepsy: A Review of Selected Clinical Syndromes and Advances in Basic Science

  title={Epilepsy: A Review of Selected Clinical Syndromes and Advances in Basic Science},
  author={Carl E. Stafstrom},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  pages={1004 - 983}
  • C. Stafstrom
  • Published 25 January 2006
  • Medicine, Biology, Psychology
  • Journal of Cerebral Blood Flow & Metabolism
Epilepsy is a common neurologic disorder that manifests in diverse ways. There are numerous seizure types and numerous mechanisms by which the brain generates seizures. The two hallmarks of seizure generation are hyperexcitability of neurons and hypersynchrony of neural circuits. A large variety of mechanisms alters the balance between excitation and inhibition to predispose a local or widespread region of the brain to hyperexcitability and hypersynchrony. This review discusses five clinical… 
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