Epilepsy: A Review of Selected Clinical Syndromes and Advances in Basic Science

@article{Stafstrom2006EpilepsyAR,
  title={Epilepsy: A Review of Selected Clinical Syndromes and Advances in Basic Science},
  author={Carl E. Stafstrom},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={2006},
  volume={26},
  pages={1004 - 983}
}
  • C. Stafstrom
  • Published 25 January 2006
  • Medicine, Biology, Psychology
  • Journal of Cerebral Blood Flow & Metabolism
Epilepsy is a common neurologic disorder that manifests in diverse ways. There are numerous seizure types and numerous mechanisms by which the brain generates seizures. The two hallmarks of seizure generation are hyperexcitability of neurons and hypersynchrony of neural circuits. A large variety of mechanisms alters the balance between excitation and inhibition to predispose a local or widespread region of the brain to hyperexcitability and hypersynchrony. This review discusses five clinical… 
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References

SHOWING 1-10 OF 224 REFERENCES
molecular pathogenesis of epilepsy: implications for therapy
TLDR
The designation of BFNC as an idiopathicepilepsy syndrome means that the disorder is not asso-ciated with a gross disturbance in brain development, energy metabolism or other aspect of brain function related to the epilepsy; indeed, most affected indi-viduals have normal neurological and intellectual development.
Pathophysiological mechanisms of genetic absence epilepsy in the rat
Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
Cortical Malformations and Epilepsy: New Insights from Animal Models
TLDR
Experimental data suggest that cortical malformations can both form epileptogenic foci and alter brain development in a manner that causes a diffuse hyperexcitability of the cortical network.
Febrile seizures in the predisposed brain: A new model of temporal lobe epilepsy
TLDR
Findings support a link between the atypical febrile seizure and mesial temporal lobe epilepsy, and establish a new model for this condition through which new preventative and therapeutic strategies can be tested.
The genetics of human epilepsy.
Mechanisms underlying epileptogenesis in cortical malformations
Chronic epilepsy and cognition
The neurobiology of temporal lobe epilepsy: too much information, not enough knowledge.
Cortical dysplasia and epilepsy: animal models.
TLDR
Animal models of cortical dysplasia provide a means by which investigators can not only study the developmental mechanisms that give rise to these brain lesions, but also examine the cause-effect relationships between structural abnormalities and epileptogenesis.
...
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