Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state

@inproceedings{Khulan2014EpigenomicPO,
  title={Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state},
  author={Batbayar Khulan and Jonathan R. Manning and Donald R. Dunbar and Jonathan R Seckl and Katri Raikkonen and Johan G Eriksson and Amanda J Drake},
  booktitle={Translational Psychiatry},
  year={2014}
}
Early-life stress (ELS) is known to be associated with an increased risk of neuropsychiatric and cardiometabolic disease in later life. One of the potential mechanisms underpinning this is through effects on the epigenome, particularly changes in DNA methylation. Using a well-phenotyped cohort of 83 men from the Helsinki Birth Cohort Study, who experienced ELS in the form of separation from their parents during childhood, and a group of 83 matched controls, we performed a genome-wide analysis… CONTINUE READING
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