Epigenomic engineering for Down syndrome

@article{Mentis2016EpigenomicEF,
  title={Epigenomic engineering for Down syndrome},
  author={A. Mentis},
  journal={Neuroscience & Biobehavioral Reviews},
  year={2016},
  volume={71},
  pages={323-327}
}
  • A. Mentis
  • Published 2016
  • Biology, Medicine
  • Neuroscience & Biobehavioral Reviews
Down syndrome (DS; trisomy 21), the commonest genetic cause of mental disability, affects approximately 250,000 families in the United States alone. Despite milestones in understanding the specific genetic causes of the syndrome, the major symptoms of DS - not least those related to neurocognitive function - are incurable. DS phenotypes are highly variable, and gene expression patterns cannot be explained by trisomy alone, implicating epigenetics in DS pathophysiology. DNA and histone… Expand
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