Epigenomic differentiation in mouse preimplantation nuclei of biparental, parthenote and cloned embryos

@article{Merico2007EpigenomicDI,
  title={Epigenomic differentiation in mouse preimplantation nuclei of biparental, parthenote and cloned embryos},
  author={Valeria Merico and J{\'e}ssica Barbieri and Maurizio Zuccotti and Boris Joffe and Thomas Cremer and Carlo Alberto Redi and Irina Solovei and Silvia Garagna},
  journal={Chromosome Research},
  year={2007},
  volume={15},
  pages={341-360}
}
Chromosomes, sub-chromosomal regions and genes are repositioned during cell differentiation to acquire a cell-type-specific spatial organization. The constraints that are responsible for this cell-type-specific spatial genome positioning are unknown. In this study we addressed the question of whether epigenetic genome modifications may represent constraints to the acquisition of a specific nuclear organization. The organization of kinetochores, pericentric heterochromatin and the nucleolus was… CONTINUE READING
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