Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis.


Osteoarthritis (OA) is a multifactorial disease subject to the effects of many genes and environmental factors. Alterations in the normal pattern of chondrocyte gene control in cartilage facilitate the onset and progression of OA. Stable changes in patterns of gene expression, not associated with alterations in DNA sequences, occur through epigenetic… (More)
DOI: 10.1016/j.molmed.2011.11.005


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