Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells

@article{Spencer2015EpigenomicAO,
  title={Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells},
  author={David H. Spencer and Maddy A. Young and Tamara L. Lamprecht and Nichole M. Helton and Robert B Fulton and Michelle D. O'Laughlin and Catrina C. Fronick and Vincent J. Magrini and Ryan T. Demeter and Christopher A Miller and Jeffery M Klco and Richard K. Wilson and Timothy J. Ley},
  journal={Leukemia},
  year={2015},
  volume={29},
  pages={1279-1289}
}
HOX genes are highly expressed in many acute myeloid leukemia (AML) samples, but the patterns of expression and associated regulatory mechanisms are not clearly understood. We analyzed RNA sequencing data from 179 primary AML samples and normal hematopoietic cells to understand the range of expression patterns in normal versus leukemic cells. HOX expression in AML was restricted to specific genes in the HOXA or HOXB loci, and was highly correlated with recurrent cytogenetic abnormalities… CONTINUE READING
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