Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer

  title={Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer},
  author={Holger Heyn and Enrique Vidal and Humberto J. Ferreira and M. Teresa Vizoso and Sergi Sayols and Antonio Bermejo G{\'o}mez and Sebastian Moran and Raquel Boque-Sastre and S{\`o}nia Guil and Anna Mart{\'i}nez-Card{\'u}s and Charles Y. Lin and Romina Royo and Jose Vicente Sanchez-Mut and Ram{\'o}n L{\'o}pez Mart{\'i}nez and Marta Gut and David Torrents and Modesto Orozco and Ivo G Gut and Richard A. Young and Manel Esteller},
  booktitle={Genome Biology},
One of the hallmarks of cancer is the disruption of gene expression patterns. Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA methylation profiles is increasingly recognized. Much of the research effort in this area has examined proximal promoter regions and epigenetic alterations at other loci are not well characterized. Using whole genome bisulfite sequencing to examine uncharted regions of the epigenome, we identify a type of far-reaching DNA… CONTINUE READING