Epigenome-wide methylation in DNA from peripheral blood as a marker of risk for breast cancer

@article{Severi2014EpigenomewideMI,
  title={Epigenome-wide methylation in DNA from peripheral blood as a marker of risk for breast cancer},
  author={Gianluca Severi and Melissa C. Southey and Dallas English and Chol-Hee Jung and Andrew Lonie and Catriona A. McLean and Helen Tsimiklis and John L. Hopper and Graham G. Giles and Laura Baglietto},
  journal={Breast Cancer Research and Treatment},
  year={2014},
  volume={148},
  pages={665-673}
}
Aberrant DNA methylation is a key feature of breast carcinoma. We aimed to test the association between breast cancer risk and epigenome-wide methylation in DNA from peripheral blood. Nested case–control study within the prospective Melbourne Collaborative Cohort Study. DNA was extracted from before-diagnosis blood samples (420 incident cases and matched controls). Methylation was measured with the Illumina Infinium Human Methylation 450 BeadChip array. Odds ratio (OR) for epigenome-wide… CONTINUE READING

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