Epigenome-wide association study of fasting blood lipids in the Genetics of Lipid-lowering Drugs and Diet Network study.

@article{Irvin2014EpigenomewideAS,
  title={Epigenome-wide association study of fasting blood lipids in the Genetics of Lipid-lowering Drugs and Diet Network study.},
  author={Marguerite R. Irvin and Degui Zhi and Roby Joehanes and Michael Mendelson and Stella W. Aslibekyan and Steven A. Claas and Krista Stanton Thibeault and Nikita S. Patel and Kenneth Day and Lindsay Waite Jones and Liming Liang and Brian H Chen and Chen Yao and Hemant K. Tiwari and Jos{\'e} M. Ordov{\'a}s and Daniel L{\'e}vy and Devin M Absher and Donna K Arnett},
  journal={Circulation},
  year={2014},
  volume={130 7},
  pages={565-72}
}
BACKGROUND Genetic research regarding blood lipids has largely focused on DNA sequence variation; few studies have explored epigenetic effects. Genome-wide surveys of DNA methylation may uncover epigenetic factors influencing lipid metabolism. METHODS AND RESULTS To identify whether differential methylation of cytosine-(phosphate)-guanine dinucleotides (CpGs) correlated with lipid phenotypes, we isolated DNA from CD4+ T cells and quantified the proportion of sample methylation at >450 000… CONTINUE READING
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