Epigenome-wide association studies (EWAS): past, present, and future.

@article{Flanagan2015EpigenomewideAS,
  title={Epigenome-wide association studies (EWAS): past, present, and future.},
  author={James M Flanagan},
  journal={Methods in molecular biology},
  year={2015},
  volume={1238},
  pages={
          51-63
        }
}
  • J. Flanagan
  • Published 31 January 2015
  • Biology
  • Methods in molecular biology
Just as genome-wide association studies (GWAS) grew from the field of genetic epidemiology, so too do epigenome-wide association studies (EWAS) derive from the burgeoning field of epigenetic epidemiology, with both aiming to understand the molecular basis for disease risk. While genetic risk of disease is currently unmodifiable, there is hope that epigenetic risk may be reversible and or modifiable. This review will take a look back at the origins of this field and revisit the past early… 
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The association between blood DNA methylation patterns at birth and lung function trajectories from childhood to adulthood is explored for the first time.
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TLDR
In this commentary, the idea of a widespread follow-up use of epigenome editing technology in EWAS studies is propagate to address the questions of which features, where in the genome, and which circumstances are essential to shape development and trigger disease states.
Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia
TLDR
The high dependence on tissues with epigenetic marks compels scientists to refine their sampling procedures, and in this review, findings obtained from brain tissue are focused on.
Bayesian reassessment of the epigenetic architecture of complex traits
TLDR
A statistical approach that estimates associations between disease risk and all measured epigenetic probes jointly, automatically controlling for both data structure and correlations among probes facilitates better understanding of the underlying epigenetic architecture of complex common disease and is applicable to any kind of genomics data.
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TLDR
Evidence remains insufficient to confidently identify or exclude rare variants or epigenetic changes in PD, and further analyses are required, using sample sizes in the tens of thousands, extensive functional annotations, and highly targeted hypothesis testing.
Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults
The molecular factors which control circulating levels of inflammatory proteins are not well understood. Furthermore, association studies between molecular probes and human traits are often performed…
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References

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TLDR
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TLDR
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TLDR
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