Epigenome-wide DNA methylation assay reveals placental epigenetic markers for noninvasive fetal single-nucleotide polymorphism genotyping in maternal plasma.

@article{Ou2014EpigenomewideDM,
  title={Epigenome-wide DNA methylation assay reveals placental epigenetic markers for noninvasive fetal single-nucleotide polymorphism genotyping in maternal plasma.},
  author={Xueling Ou and Huan Wang and Dongyang Qu and Yongzhen Chen and Jun Gao and Hongyu Sun},
  journal={Transfusion},
  year={2014},
  volume={54 10},
  pages={2523-33}
}
BACKGROUND The use of DNA methylation difference between maternal blood cell and fetal (placental) DNA is one of the main areas of interest for the development of fetal epigenetics markers in maternal plasma. STUDY DESIGN AND METHODS We employed a methylation array (HumanMethylation450 array, Illumina, Inc.) to identify novel biomarkers that are specially hypermethylated in placental DNA versus maternal blood cells in a genome-wide basis. Validation by bisulfite genomic sequencing was… CONTINUE READING
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