Epigenome mapping in normal and disease States.

  title={Epigenome mapping in normal and disease States.},
  author={Alika K Maunakea and Iouri Chepelev and Keji Zhao},
  journal={Circulation research},
  volume={107 3},
Epigenomes are comprised, in part, of all genome-wide chromatin modifications, including DNA methylation and histone modifications. Unlike the genome, epigenomes are dynamic during development and differentiation to establish and maintain cell type-specific gene expression states that underlie cellular identity and function. Chromatin modifications are particularly labile, providing a mechanism for organisms to respond and adapt to environmental cues. Results from studies in animal models… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 61 extracted citations


Publications referenced by this paper.
Showing 1-10 of 171 references

Similar Papers

Loading similar papers…