Epigenome mapping in normal and disease States.

@article{Maunakea2010EpigenomeMI,
  title={Epigenome mapping in normal and disease States.},
  author={Alika K Maunakea and Iouri Chepelev and Keji Zhao},
  journal={Circulation research},
  year={2010},
  volume={107 3},
  pages={327-39}
}
Epigenomes are comprised, in part, of all genome-wide chromatin modifications, including DNA methylation and histone modifications. Unlike the genome, epigenomes are dynamic during development and differentiation to establish and maintain cell type-specific gene expression states that underlie cellular identity and function. Chromatin modifications are particularly labile, providing a mechanism for organisms to respond and adapt to environmental cues. Results from studies in animal models… CONTINUE READING

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