Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood

  title={Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood},
  author={L. Buckley and M. Lacey and M. Ehrlich},
  pages={13 - 31}
  • L. Buckley, M. Lacey, M. Ehrlich
  • Published 2016
  • Biology, Medicine
  • Epigenomics
  • Aim: Identify epigenetic marks in the vicinity of DMPK (linked to myotonic dystrophy, DM1) that help explain tissue-specific differences in its expression. Materials & methods: At DMPK and its flanking genes (DMWD, SIX5, BHMG1 and RSPH6A), we analyzed many epigenetic and transcription profiles from myoblasts, myotubes, skeletal muscle, heart and 30 nonmuscle samples. Results: In the DMPK gene neighborhood, muscle-associated DNA hypermethylation and hypomethylation, enhancer chromatin, and CTCF… CONTINUE READING
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