Epigenetics of Personality Traits: An Illustrative Study of Identical Twins Discordant for Risk-Taking Behavior

  title={Epigenetics of Personality Traits: An Illustrative Study of Identical Twins Discordant for Risk-Taking Behavior},
  author={Zachary A. Kaminsky and Artūras Petronis and Sun-Chong Wang and Brian Levine and Omar Ghaffar and Darlene P. Floden and Anthony Feinstein},
  journal={Twin Research and Human Genetics},
  pages={1 - 11}
Abstract DNA methylation differences between identical twins could account for phenotypic twin discordance of behavioral traits and diseases. High throughput epigenomic microarray profiling can be a strategy of choice for identification of epigenetic differences in phenotypically different monozygotic (MZ) twins. Epigenomic profiling of a pair of MZ twins with quantified measures of psychometric discordance identified several DNA methylation differences, some of which may have developmental and… 
DNA methylation variations between mono - and dizygotic twins
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Epigenetics of discordant monozygotic twins: implications for disease
Advances in epigenetic studies of discordant MZ twins, focusing on disease, help to identify epigenetic markers of environmental risk and molecular mechanisms involved in disease and disease progression, which have implications both for understanding disease and for future medical research.
The value of twins in epigenetic epidemiology.
The strategic use of identical twins discordant for complex disease has revealed the importance of linking epigenetic disruption to the disease-associated risk in humans, and the possibility that epigenetic effects on disease may in part explain some of the missing heritability in genome-wide association studies.
Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth
Estimation of genome-wide DNA methylation using the 450 K Illumina BeadChip in a sample of 37 MZ twin pairs found that some genes were stable while others were unstable, suggesting that the methylome remains dynamic in adolescence and that dynamic sites tend to be organized in certain gene pathways.
Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences
The subject of epigenetics is explored as another component in human phenotypic variability and its links to disease focusing particularly on evidence from MZ twin studies.
Investigating the Relationship Between Aging and Epigenetic Differences in Monozygotic Twins
  • Wynnie Feng
  • Medicine
    Proceedings of the 2022 International Conference on Creative Industry and Knowledge Economy (CIKE 2022)
  • 2022
This study is going to compare epigenetic profiles of monozygotic twin siblings of varying ages and genders and examines DNA methylation as well as histone acetylation patterns in the H3 and H4 histone regions.
Author ' s response to reviews Title : Twin discordance and disease : not just an environmental cause ?
The subject of epigenetics is explored as another component in human phenotypic variability focusing on evidence from MZ twin studies and a range of early environmental factors that need to be considered as potentially explaining MZ twins discordance.
Differences of DNA methylation profiles between monozygotic twins’ blood samples
It is suggested that CpG methylation profile could be a useful biomarker in individual identification of MZs, which exhibited remarkable differences of genome-wide 5-methylcytosine.
The Utility of Twins for Epigenetic Analysis
Twin studies are generating compelling evidence linking epigenetic disruption to the disease-associated risk in humans and revealed the importance of genetic factors and both in utero and postnatal environments to the establishment and maintenance of the human epigenome.
DNA methylation and blood pressure in Chinese adult twins


Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?
Although the epigenetic analysis was conducted for only several hundred base pairs of DRD2, the fact that numerous studies identified nonuniform methylation patterns across the clones of bisulfite-modified DNA from the same individual, as well as non uniform patterns across different individuals, argues for the universality of intra- and interindividual epigenetic variation.
Epigenetic differences arise during the lifetime of monozygotic twins.
Older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait, indicating how an appreciation of epigenetics is missing from the understanding of how different phenotypes can be originated from the same genotype.
Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus.
Variation in DNA methylation of the IGF2/H19 locus is mainly determined by heritable factors and single nucleotide polymorphisms (SNPs) in cis, rather than the cumulative effect of environmental and stochastic factors occurring with age.
Phenotypic differences in genetically identical organisms: the epigenetic perspective.
Epigenetic mechanisms may explain paradoxical findings in twin and inbred animal studies when Phenotypic differences occur in the absence of observable environmental differences and also when environmental differences do not significantly increase the degree of phenotypic variation.
Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
The results suggest that altered DNA methylation statuses of PPIEL might have some significance in pathophysiology of bipolar disorder.
The DNA methylation profile within the 5′-regulatory region of DRD2 in discordant sib pairs with schizophrenia
Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.
It is confirmed that this CpG island does function as a promoter in vitro and that its activity is inversely proportional to the extent of methylation, raising the possibility that hypermethylation of the AXIN1 promoter, by mechanisms as yet undetermined, is associated with the malformation.
Personality and risk-taking: common biosocial factors.
Biological traits associated with both risk-taking and personality, particularly sensation seeking, such as the D4 dopamine receptor gene, the enzyme monoamine oxidase, and augmenting or reducing of the cortical evoked potential are discussed.
Microarray-based DNA methylation profiling: technology and applications
The advantages of using the unmethylated DNA fraction versus the methylated one, which substantially improve the chances of detecting DNA methylation differences, are demonstrated.
Methylation dynamics, epigenetic fidelity and X chromosome structure.
DNA methylation of the X chromosome is reviewed and discussed, with emphasis on the partial methylation seen in the mouse X-linked Pgk1 promoter region, and chromatin accessibility differences between the active X chromosome (Xa) and the inactive X chromosomes (Xi).