Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score.

@article{Marcucci2014EpigeneticsMG,
  title={Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score.},
  author={Guido Marcucci and Pearlly Yan and Kati S. Maharry and David Frankhouser and Deedra Nicolet and Klaus H Metzeler and Jessica Kohlschmidt and Krzysztof Mr{\'o}zek and Yue-zhong Wu and Donna Bucci and John Curfman and Susan P. Whitman and Ann-Kathrin Eisfeld and Jason H Mendler and Sebastian Schwind and Heiko Becker and Constance Baer and Andrew J. Carroll and Maria R. Baer and Meir Wetzler and Thomas H. Carter and Bayard L. Powell and Jonathan E Kolitz and John C. Byrd and Christoph Plass and Ramiro Garzon and Michael A. Caligiuri and Richard M Stone and Stefano Volinia and Ralf Bundschuh and Clara D. Bloomfield},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2014},
  volume={32 6},
  pages={548-56}
}
PURPOSE Molecular risk stratification of acute myeloid leukemia (AML) is largely based on genetic markers. However, epigenetic changes, including DNA methylation, deregulate gene expression and may also have prognostic impact. We evaluated the clinical relevance of integrating DNA methylation and genetic information in AML. METHODS Next-generation… CONTINUE READING