Epigenetics in spermatogenesis.

  title={Epigenetics in spermatogenesis.},
  author={Jacquetta M. Trasler},
  journal={Molecular and cellular endocrinology},
  volume={306 1-2},
DNA methylation is a heritable epigenetic modification of cytosine residues within CpG dinucleotides associated with the modulation of gene expression and found at 20-30 million sites throughout the mammalian genome. The methylation of DNA is catalyzed by DNA (cytosine-5)-methyltransferases (DNMTs), regulates genes during development and plays a role in genomic imprinting and X inactivation. Abnormalities in DNA methylation lead to growth and behavioral abnormalities as well as cancer. Genomic… CONTINUE READING


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