Epigenetics in cancer: implications for early detection and prevention.

  title={Epigenetics in cancer: implications for early detection and prevention.},
  author={Mukesh Verma and Sudhir K. Srivastava},
  journal={The Lancet. Oncology},
  volume={3 12},
Knowledge of the molecular events that occur during the early stages of cancer has advanced rapidly. The initiation and development of cancer involves several molecular changes, which include epigenetic alterations. Epigenetics is the study of modifications in gene expression that do not involve changes in DNA nucleotide sequences. Modifications in gene expression through methylation of DNA and remodelling of chromatin via histone proteins are believed to be the most important of the epigenetic… CONTINUE READING

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