Epigenetics and eating disorders

@article{Pjetri2012EpigeneticsAE,
  title={Epigenetics and eating disorders},
  author={Eneda Pjetri and Ulrike Schmidt and Martien J. H. Kas and Iain C. Campbell},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  year={2012},
  volume={15},
  pages={330–335}
}
Purpose of reviewEating disorders are complex psychiatric disorders in which genes, environment, and gene–environment interactions (G×E) have a role. Such G×E may occur in adulthood or during development. They may also be modified by factors such as (mal)nutrition or stress and this may result in acute or long-term epigenetic modifications. This review discusses the potential for recent developments in epigenetics to address ongoing aetiological issues in eating disorders. Recent… 
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Epigenetic mechanisms, which modulate gene expression, are becoming increasingly important in the research on anorexia nervosa (AN). Patients with AN have difficulties with the perception of hunger
Differential Methylation of the Oxytocin Receptor Gene in Patients with Anorexia Nervosa: A Pilot Study
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Epigenetic misregulation of the OXTR gene may be implicated in anorexia nervosa, which may either be a mechanism linking environmental adversity to risk or may be a secondary consequence of the illness.
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TLDR
This review presents an overview concerning the actual pharmacological and psychological treatments, the knowledge of cells, circuits, neuropeptides, neuromodulators and hormones in the human brain- and other organs- underlying these disorders, the studies in animal models and, finally, the genetic approaches devoted to face this challenge.
Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa.
TLDR
The transcriptional regulation of the endocannabinoid system, an interesting target for body weight maintenance and the control of food intake and energy balance, supports a possible role for Cnr1 in the ABA animal model of anorexia nervosa.
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References

SHOWING 1-10 OF 57 REFERENCES
Eating disorders, gene–environment interactions and epigenetics
TLDR
It is described how environmental factors such as those associated with nutrition and/or stress may cause epigenetic changes which have transcriptional and phenotypic effects, which alter the long term risk of developing an eating disorder.
Epigenetic dysregulation of dopaminergic genes in eating disorders.
TLDR
A disturbed expression of dopaminergic genes that is accompanied by a dysregulation of the epigenetic DNA methylation is shown in the blood of patients suffering from eating disorders.
Animal models of eating disorder traits.
  • M. Kas, R. Adan
  • Medicine, Psychology
    Current topics in behavioral neurosciences
  • 2011
TLDR
Novel mouse genetic and phenotyping tools offer a way to study neurobehavioral traits under controlled environmental and genetic background conditions and will be relevant to develop new therapies for patients within the heterogeneous eating disorder populations.
Using Animal Models to Disentangle the Role of Genetic, Epigenetic, and Environmental Influences on Behavioral Outcomes Associated with Maternal Anxiety and Depression
TLDR
Characterization of these two inbred mouse inbred strains over the course of pregnancy and in the postpartum period for behavioral and neuroendocrine changes may provide useful information by which to inform human studies, leading to advances in understanding of the etiology of anxiety and depression and the role of genetics and the environment.
The heritability of eating disorders: methods and current findings.
TLDR
This chapter reviews biometrical genetic methods and current findings from family and twin studies that investigate the role of genes and environment in the etiology of eating disorders, and discusses the implications of this research for the basic conceptualization of Eating disorders and the future value of twin modeling in the molecular genetic era.
Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events
TLDR
The data provide insights into the molecular mechanisms underlying the susceptibility and adaptation to chronic stress within the brain, suggesting that epigenetic modifications of Gdnf, along with genetic and environmental factors, contribute to behavioral responses to stress.
Early nutrition and epigenetic programming: chasing shadows
TLDR
This review focuses on recently discovered mechanisms and calls into question prevailing views about the dynamics, positions and functions of relevant epigenetic marks, as well as revealing additional complexity in epigenetic processes.
Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
TLDR
A genome-wide analysis of DNA methylation on peripheral blood DNA samples obtained from a unique sample of MZ twin pairs discordant for major psychosis provides further evidence to support a role forDNA methylation differences in mediating phenotypic differences between MZ twins and in the etiology of both SZ and BD.
Epigenetic Downregulation of Atrial Natriuretic Peptide but not Vasopressin mRNA Expression in Females with Eating Disorders is Related to Impulsivity
TLDR
It is concluded that epigenetic mechanisms may contribute to the known alterations of ANP homeostasis in women with eating disorders.
Promoter specific DNA methylation and gene expression of POMC in acutely underweight and recovered patients with anorexia nervosa.
TLDR
Preliminary data on pattern of POMC regulation suggests an association with the underweight state rather than with persisting trait markers of AN, which may represent a counterregulatory mechanism as part of the crosstalk between the immune and neuroendocrine systems.
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2
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