Epigenetics and eating disorders

@article{Pjetri2012EpigeneticsAE,
  title={Epigenetics and eating disorders},
  author={Eneda Pjetri and Ulrike Schmidt and Martien J. H. Kas and Iain C. Campbell},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  year={2012},
  volume={15},
  pages={330–335}
}
  • E. PjetriU. Schmidt I. Campbell
  • Published 1 July 2012
  • Psychology, Biology, Medicine
  • Current Opinion in Clinical Nutrition and Metabolic Care
Purpose of reviewEating disorders are complex psychiatric disorders in which genes, environment, and gene–environment interactions (G×E) have a role. Such G×E may occur in adulthood or during development. They may also be modified by factors such as (mal)nutrition or stress and this may result in acute or long-term epigenetic modifications. This review discusses the potential for recent developments in epigenetics to address ongoing aetiological issues in eating disorders. Recent… 

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References

SHOWING 1-10 OF 57 REFERENCES

Epigenetic dysregulation of dopaminergic genes in eating disorders.

A disturbed expression of dopaminergic genes that is accompanied by a dysregulation of the epigenetic DNA methylation is shown in the blood of patients suffering from eating disorders.

Animal models of eating disorder traits.

  • M. KasR. Adan
  • Psychology, Biology
    Current topics in behavioral neurosciences
  • 2011
Novel mouse genetic and phenotyping tools offer a way to study neurobehavioral traits under controlled environmental and genetic background conditions and will be relevant to develop new therapies for patients within the heterogeneous eating disorder populations.

Using Animal Models to Disentangle the Role of Genetic, Epigenetic, and Environmental Influences on Behavioral Outcomes Associated with Maternal Anxiety and Depression

Characterization of these two inbred mouse inbred strains over the course of pregnancy and in the postpartum period for behavioral and neuroendocrine changes may provide useful information by which to inform human studies, leading to advances in understanding of the etiology of anxiety and depression and the role of genetics and the environment.

The heritability of eating disorders: methods and current findings.

This chapter reviews biometrical genetic methods and current findings from family and twin studies that investigate the role of genes and environment in the etiology of eating disorders, and discusses the implications of this research for the basic conceptualization of Eating disorders and the future value of twin modeling in the molecular genetic era.

Early nutrition and epigenetic programming: chasing shadows

This review focuses on recently discovered mechanisms and calls into question prevailing views about the dynamics, positions and functions of relevant epigenetic marks, as well as revealing additional complexity in epigenetic processes.

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

A genome-wide analysis of DNA methylation on peripheral blood DNA samples obtained from a unique sample of MZ twin pairs discordant for major psychosis provides further evidence to support a role forDNA methylation differences in mediating phenotypic differences between MZ twins and in the etiology of both SZ and BD.

Epigenetic Downregulation of Atrial Natriuretic Peptide but not Vasopressin mRNA Expression in Females with Eating Disorders is Related to Impulsivity

It is concluded that epigenetic mechanisms may contribute to the known alterations of ANP homeostasis in women with eating disorders.
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