Epigenetics and DNA methylation come of age in toxicology.

  title={Epigenetics and DNA methylation come of age in toxicology.},
  author={Rebecca E Watson and Jay I. Goodman},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={67 1},
A wide variety of chemical and physical agents have the potential to produce adverse effects by causing heritable changes to the genome, resulting in heritable alterations in phenotype. These are often assumed to be a consequence of mutation. However, mutagenesis is not the only mechanism underlying heritable alterations to the genome. It is important to understand that there may also be an epigenetic basis for this. DNA methylation is the epigenetic mechanism that this review focuses upon. We… CONTINUE READING
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