Epigenetics Lessons from Twins: Prospects for Autoimmune Disease

  title={Epigenetics Lessons from Twins: Prospects for Autoimmune Disease},
  author={Esteban Ballestar},
  journal={Clinical Reviews in Allergy \& Immunology},
  • E. Ballestar
  • Published 1 August 2010
  • Biology
  • Clinical Reviews in Allergy & Immunology
The existence of phenotypic differences between monozygotic (MZ) twins is a prime case where the relationship between genetic determinants and environmental factors is illustrated. Although virtually identical from a genetic point of view, MZ twins show a variable degree of discordance with respect to different features including susceptibility to disease. Discordance has frequently been interpreted in terms of the impact of the environment with genetics. In this sense, accumulated evidence… 
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