Epigenetics: poly(ADP‐ribosyl)ation of PARP‐1 regulates genomic methylation patterns

@article{Caiafa2009EpigeneticsPO,
  title={Epigenetics: poly(ADP‐ribosyl)ation of PARP‐1 regulates genomic methylation patterns},
  author={Paola Caiafa and T. Guastafierro and Michele Zampieri},
  journal={The FASEB Journal},
  year={2009},
  volume={23},
  pages={672 - 678}
}
In the postgenome era, attention is being focused on those epigenetic modifications that modulate chromatin structure to guarantee that information present on DNA is read correctly and at the most appropriate time to meet cellular requirements. Data reviewed show that along the chain of events that induce DNA methylation‐dependent chromatin condensation/decondensation, a postsynthetic modification other than histone acetylation, phosphorylation, and methylation—namely poly(ADP‐ribosyl)ation… 

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