Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene.

@article{Fu2009EpigeneticsIG,
  title={Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene.},
  author={Qinyouen Fu and Xing Yu and Christopher W. Callaway and Robert Hooijberg Nancy Lane and Robert A McKnight},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 8},
  pages={2438-49}
}
Intrauterine growth restriction (IUGR) decreases serum insulin growth factor-1 (IGF-1) levels. IGF-1 is an epigenetically regulated gene that has two promoters, alternative exon 5 splicing, and multiple termination sites. The regulation of gene expression involves the whole gene, as evidenced by the aforementioned IGF-1 paradigm. We hypothesized that IUGR in the rat would affect hepatic IGF-1 expression and alter the epigenetic characteristics of the IGF-1 gene along its length. IUGR was… CONTINUE READING