Epigenetics: a link between addiction and social environment

  title={Epigenetics: a link between addiction and social environment},
  author={Duyilemi Chris Ajonijebu and Oualid Abboussi and Vivienne Ann Russell and Musa Vuyisile Mabandla and William M. U. Daniels},
  journal={Cellular and Molecular Life Sciences},
The detrimental effects of drug abuse are apparently not limited to individuals but may also impact the vulnerability of their progenies to develop addictive behaviours. Epigenetic signatures, early life experience and environmental factors, converge to influence gene expression patterns in addiction phenotypes and consequently may serve as mediators of behavioural trait transmission between generations. The majority of studies investigating the role of epigenetics in addiction do not consider… 

The Role of Epigenetics in Addiction: Clinical Overview and Recent Updates.

This book chapter is a non-systematic literature review of the recent publications tackling the topic of epigenetics in addiction, which is a promising foundation for future research of molecules that target specific brain regions and their functions to address core behavioral changes seen in addiction.

Adolescent Substance Abuse, Transgenerational Consequences and Epigenetics

Much of the new data discussed here is from animal models, indicating that future clinical studies are much needed to better understand the neurobiological consequences and mechanisms of drug actions on the human brains’ development and maturation.

The interaction between Environmental Enrichment and fluoxetine in inhibiting sucrose-seeking renewal in mice depend on social living condition

The data show that social environment may influence the EE/fluoxetine interaction in inhibiting relapse to sucrose, and suggest that setting up proper living conditions to boost the efficacy of therapeutic approaches may represent a fundamental strategy to treat addiction disorders.

Narrative review on potential role of gut microbiota in certain substance addiction

Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD)

It is envisaged that GARS type of screening will provide a novel opportunity to help identify causal pathways and associated mechanisms of genetic factors, psychological characteristics, and addictions awaiting additional scientific evidence including a future meta- analysis of all available data.

Histone deacetylase inhibition differentially attenuates cue-induced reinstatement: An interaction of environment and acH3K9 expression in the dorsal striatum.

While IC rats exhibit less acH3K9 expression in the DSt, future studies are needed to elucidate the critical epigenetic factors that drive substance abuse, particularly in vulnerable populations.

Animal models in addiction research: A dimensional approach

Cocaine-induced inheritable epigenetic marks may be altered by changing early postnatal fostering.

The data provide some evidence that indirect exposure to cocaine may cause marked epigenetic changes within the cortical networks of drug-naive descendants and that mediation by Crem/Fosb signalling in this brain region may be beneficial, while early postnatal fostering may further modify the accompanied neurochemical and functional components.

An overview about DNA methylation in childhood obesity: Characteristics of the studies and main findings

The aim of this review is to discuss this heterogeneity and point out some aspects that should be considered in future studies to clarify the role of DNA methylation in childhood obesity.



Epigenetics of Stress, Addiction, and Resilience: Therapeutic Implications

  • J. Cadet
  • Psychology, Biology
    Molecular Neurobiology
  • 2014
The possibility that treatment of addiction should involve cognitive and pharmacological approaches that enhance resilience in at risk individuals is suggested and similar approaches should also be used with patients who have already succumbed to the nefarious effects of addictive substances.

Epigenetic influence of social experiences across the lifespan.

  • F. Champagne
  • Psychology, Biology
    Developmental psychobiology
  • 2010
In this review, recent studies which highlight the epigenetic effects of parent-offspring, peer and adult social interactions both with and across generations will be discussed and the implications of this research for understanding the developmental origins of individual differences in brain and behavior will be explored.

Epigenetic mechanisms in drug addiction.

Epigenetic Regulation in Substance Use Disorders

Understanding these mechanisms that establish and maintain drug-dependent plasticity changes may lead to deeper understanding of substance use disorders as well as novel approaches to treatment.

Epigenetic mechanisms mediating the long-term effects of maternal care on development

Chromatin regulation in drug addiction and depression

Recent findings from behavioral, molecular, and bioinformatic approaches that are used to understand the complex epigenetic regulation of gene expression in brain by drugs of abuse and by stress promise to open up new avenues for improved treatments of these disorders.

Modeling the role of environment in addiction

Early-life stress interactions with the epigenome: potential mechanisms driving vulnerability toward psychiatric illness

The current animal literature demonstrating ELS-induced epigenetic modulation of gene expression that results in altered adult phenotypes is discussed, and the new field of neuroepigenetics has emerged as a potential mechanism underlying environmental and genetic interactions.

Fetal Alcohol Spectrum Disorders: The Epigenetic Perspective1

An epigenetic model suggests that the concept of a “fetal alcohol spectrum” should be expanded to include “preconceptional effects,” highlighting the urgency of research into the epigenetic basis of FASDs.

Epigenetic Inheritance of Disease and Disease Risk

Examination of the challenging possibility that epigenetic changes induced by environmental factors can contribute to some of the inheritance of disease and disease risk reveals potential novel strategies for diagnosis and treatment.