Epigenetics: Connecting Environment and Genotype to Phenotype and Disease

  title={Epigenetics: Connecting Environment and Genotype to Phenotype and Disease},
  author={S P Barros and Steven Offenbacher},
  journal={Journal of Dental Research},
  pages={400 - 408}
Genetic information is encoded not only by the linear sequence of DNA, but also by epigenetic modifications of chromatin structure that include DNA methylation and covalent modifications of the proteins that bind DNA. These “epigenetic marks” alter the structure of chromatin to influence gene expression. Methylation occurs naturally on cytosine bases at CpG sequences and is involved in controlling the correct expression of genes. DNA methylation is usually associated with triggering histone… 

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