Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma.

@article{Chen2011EpigeneticsMA,
  title={Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma.},
  author={Xiaoyan Chen and Jiao Wang and Huanjun Shen and Juan J. Lu and Canxia Li and Dan-Ning Hu and Xiang Da Eric Dong and Dongsheng Yan and Lili Tu},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 3},
  pages={1193-9}
}
PURPOSE MicroRNAs (miRNAs) can contribute to tumorigenesis by acting as either oncogenes or tumor suppressor genes. The authors' previous studies on miR-34a showed that miRNA can influence the growth of uveal melanoma cells. In this study, they investigated the role of miR-137 in the pathogenesis of uveal melanoma. METHODS Real-time RT-PCR was used to screen the expression levels of miR-137 in uveal melanocytes and uveal melanoma cell lines. Cell proliferation was examined by MTS assay and… CONTINUE READING