Epigenetic variability and the evolution of human cancer.

  title={Epigenetic variability and the evolution of human cancer.},
  author={Rolf Ohlsson and Chandrasekhar Kanduri and Joanne Whitehead and Susan Ohlsson Pfeifer and Victor A Lobanenkov and Andrew P. Feinberg},
  journal={Advances in cancer research},
Although the leading dogma for the origin of the diversity in cancer cell subpopulations is based on a stepwise selection and accumulation of genetic changes that allow uncontrollable malignant growth, there is an emerging understanding that the variability of heritable phenotypes in cancer and cancer-prone cells may also involve epigenetic mechanisms. We discuss here experimental data that allow us to postulate that the genome is organized into epigenetic territories with lineage-specific… CONTINUE READING