Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylases

  title={Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylases},
  author={F. Vendetti and C. Rudin},
  journal={Expert Opinion on Biological Therapy},
  pages={1273 - 1285}
  • F. Vendetti, C. Rudin
  • Published 2013
  • Biology, Medicine
  • Expert Opinion on Biological Therapy
  • Introduction: Epigenetics refers to heritable modifications of DNA and associated chromatin components that influence gene expression without altering DNA coding sequence. Epigenetic dysregulation is a central contributor to oncogenesis and is increasingly a focus of interest in cancer therapeutic research. Two key levels of aberrant epigenetic control are DNA methylation and histone acetylation. Primary regulators of these epigenetic changes include DNA methyltransferases (DNMTs) and histone… CONTINUE READING
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