Epigenetic therapy--a new development in pharmacology.

@article{Peedicayil2006EpigeneticTN,
  title={Epigenetic therapy--a new development in pharmacology.},
  author={Jacob Peedicayil},
  journal={The Indian journal of medical research},
  year={2006},
  volume={123 1},
  pages={17-24}
}
Epigenetics, heritable changes in gene expression that do not involve changes in DNA sequence, is known to be involved in disease. Two important epigenetic changes that are known to contribute to disease are abnormal methylation patterns of DNA and modifications of histones in chromatin. This review describes a new development in pharmacology, epigenetic therapy, which attempts to correct these changes. At present two groups of drugs are being developed. One inhibits DNA methyltransferases… CONTINUE READING