Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells.

@article{Sharma2008EpigeneticTF,
  title={Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells.},
  author={Rohita Sharma and Thomas Ottenhof and Paulina A. Rzeczkowska and Lennard P Niles},
  journal={Journal of pineal research},
  year={2008},
  volume={45 3},
  pages={277-84}
}
We have reported the induction of glial cell line-derived neurotrophic factor, a potent survival factor for dopaminergic neurons, in the C17.2 neural stem cell line following in vitro treatment with melatonin. Furthermore, we have detected the melatonin MT(1) receptor in these cells. Given these findings and recent evidence that melatonin may play a role in… CONTINUE READING