Epigenetic switch from posttranscriptional to transcriptional silencing is correlated with promoter hypermethylation.

@article{Fojtov2003EpigeneticSF,
  title={Epigenetic switch from posttranscriptional to transcriptional silencing is correlated with promoter hypermethylation.},
  author={Miloslava Fojtov{\'a} and Helena Van Houdt and Anna Depicker and Ale{\vs} Kovař{\'i}k},
  journal={Plant physiology},
  year={2003},
  volume={133 3},
  pages={1240-50}
}
Changes in the distribution of methylcytosine residues along a transgene locus of tobacco (Nicotiana tabacum) in relation to the type of gene silencing were studied in parental plant leaves, calli, and regenerated plants derived thereof. Parental-silenced HeLo1 (hemizygous for locus 1) plants show posttranscriptional silencing of the residing nptII (neomycin phosphotransferase II) transgene and cytosine methylation restricted to the 3' end and center part of the transcribed region. Here, we… CONTINUE READING