Epigenetic stem cell signature in cancer

@article{Widschwendter2007EpigeneticSC,
  title={Epigenetic stem cell signature in cancer},
  author={Martin Widschwendter and Heidi Fiegl and Daniel Egle and Elisabeth Mueller-Holzner and Gilbert Spizzo and Christian Marth and Daniel J. Weisenberger and Mihaela Campan and Joanne Alison Young and Ian Jacobs and Peter W. Laird},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={157-158}
}
Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation. 
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