Epigenetic status in the offspring of spontaneous and assisted conception.

@article{Whitelaw2014EpigeneticSI,
  title={Epigenetic status in the offspring of spontaneous and assisted conception.},
  author={Natalie Whitelaw and Siladitya Bhattacharya and G. V. Hoad and Graham W. Horgan and Mark P. R. Hamilton and Paul Haggarty},
  journal={Human reproduction},
  year={2014},
  volume={29 7},
  pages={1452-8}
}
STUDY QUESTION Is DNA methylation in buccal cell DNA from children born following IVF (in vitro fertilization) and ICSI (intra-cytoplasmic sperm injection) different from that of spontaneously conceived children? SUMMARY ANSWER DNA methylation in the imprinted gene, small nuclear ribonucleoprotein polypeptide N (SNRPN), was higher in children conceived by ICSI and in those born to women with the longest duration of infertility regardless of the method of conception. WHAT IS KNOWN ALREADY… CONTINUE READING