Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia.

@article{Agirre2009EpigeneticSO,
  title={Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia.},
  author={Xabier Agirre and Amaia Vilas-Zornoza and Antonio Jim{\'e}nez-Velasco and Jos{\'e} Ignacio Mart{\'i}n-Subero and Lucia Cordeu and Leire G{\'a}rate and Edurne San Jos{\'e}-En{\'e}riz and Gloria Abizanda and Paula Rodr{\'i}guez-Otero and Puri Fortes and J. Rif{\'o}n and Eva Bandr{\'e}s and Mar{\'i}a Jos{\'e} Calasanz and Vanesa Mart{\'i}n and Anabel Heiniger and Antoni Torres and Reiner Siebert and Jos{\'e} Rom{\'a}n-G{\'o}mez and Felipe Pr{\'o}sper},
  journal={Cancer research},
  year={2009},
  volume={69 10},
  pages={4443-53}
}
Whereas transcriptional silencing of genes due to epigenetic mechanisms is one of the most important alterations in acute lymphoblastic leukemia (ALL), some recent studies indicate that DNA methylation contributes to down-regulation of miRNAs during tumorigenesis. To explore the epigenetic alterations of miRNAs in ALL, we analyzed the methylation and chromatin status of the miR-124a loci in ALL. Expression of miR-124a was down-regulated in ALL by hypermethylation of the promoter and histone… CONTINUE READING
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Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective Research

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