Epigenetic silencing of the endothelin-B receptor gene in non-small cell lung cancer.

@article{Knight2009EpigeneticSO,
  title={Epigenetic silencing of the endothelin-B receptor gene in non-small cell lung cancer.},
  author={Lucy J Knight and Joseph Burrage and Sarah R. Bujac and Carolyn Haggerty and Alexander Harold Graham and Neil J. Gibson and Gillian Ellison and James W Growcott and Angela N. Brooks and Andrew M Hughes and George E Xinarianos and Georgios Nikolaidis and John K. Field and Triantafillos Liloglou},
  journal={International journal of oncology},
  year={2009},
  volume={34 2},
  pages={465-71}
}
Endothelin-1 is overexpressed in several tumor types. Activation of the endothelin-A (ETA) receptor may promote cell growth, angiogenesis and invasion, and inhibits the apoptotic process, while activation of the endothelin-B (ETB) receptor may induce cell death by apoptosis and inhibit tumor progression. Hypermethylation and subsequent silencing of the ETB receptor gene promoter has been reported in some cancer types. As the endothelin pathway is subject to research for pharmacological cancer… CONTINUE READING

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