Epigenetic silencing of the PTEN gene in melanoma.

  title={Epigenetic silencing of the PTEN gene in melanoma.},
  author={Alireza Mirmohammadsadegh and Alessandra Marini and Sandeep Nambiar and Mohamed L. Hassan and Andrea Tannapfel and Thomas Ruzicka and Ulrich R. Hengge},
  journal={Cancer research},
  volume={66 13},
Phosphatase and tensin homologue deleted from chromosome 10 (PTEN) seems to be an important tumor suppressor gene in melanoma. Because the PTEN gene is only infrequently deleted or mutated, and because the PTEN protein is low to absent in a significant number of melanomas, we investigated alternative methods of epigenetic silencing. We did quantitative positional methylation analysis (pyrosequencing) on 37 sera from melanoma patients and on 21 pairs of corresponding sera and melanoma specimens… CONTINUE READING


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