Epigenetic silencing of miR-124 prevents spermine oxidase regulation: Implications for Helicobacter pylori-induced gastric cancer

@inproceedings{MurrayStewart2016EpigeneticSO,
  title={Epigenetic silencing of miR-124 prevents spermine oxidase regulation: Implications for Helicobacter pylori-induced gastric cancer},
  author={Tracy Murray-Stewart and Johanna Carolina Sierra and M Blanca Piazuelo and Robertino M. Mera and Riteshwari Chaturvedi and Luis Eduardo Bravo and P. Dom{\'i}nguez Correa and Barbara G. Schneider and Keith T Wilson and Robert Anthony Casero},
  booktitle={Oncogene},
  year={2016}
}
Chronic inflammation contributes to the development of various forms of cancer. The polyamine catabolic enzyme spermine oxidase (SMOX) is induced in chronic inflammatory conditions, including Helicobacter pylori-associated gastritis, where its production of hydrogen peroxide contributes to DNA damage and subsequent tumorigenesis. MicroRNA expression levels are also altered in inflammatory conditions; specifically, the tumor suppressor miR-124 becomes silenced by DNA methylation. We sought to… CONTINUE READING
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